Chemosensitization of Resistant Breast and Prostate Cancer Cells by Selective Aryl Hydrocarbon Receptor Modulators (sahrms)
نویسندگان
چکیده
Recent reports indicate that SAhRMs such as 3, 3’-diindolylmethane (DIM) inhibit α-estrogen receptor (ER) expression and estrogen signaling in human breast cancer cells and inhibit androgen receptor (AR) signaling in human prostate cancer cells. DIM is an AhR agonist derived from Brassica vegetables and has been shown to have antiproliferative and proapoptotic effects in breast and prostate cancer cells. α-naphthoflavone (ANF) belongs to the family of flavonoids and is an AhR antagonist.
منابع مشابه
Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cells.
Leflunomide, flutamide, nimodipine, mexiletine, sulindac, tranilast, 4-hydroxytamoxifen, and omeprazole are pharmaceuticals previously characterized as aryl hydrocarbon receptor (AHR) agonists in various cell lines and animal models. In this study, the eight AHR-active pharmaceuticals were investigated in highly aggressive aryl hydrocarbon (Ah)-responsive BT474 and MDA-MB-468 breast cancer cell...
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